SIN 14

Overview

SIN 14, a derivative of Sinomenine ( HY-15122 ), is an orally active HO-1 activator ( K D = 17.2 μM). SIN 14 binds to the catalytic core domain of HO-1 and induces HO-1 activation in catalysis. SIN 14 significantly increases HO-1 stability. SIN 14 has anti-inflammatory effects and inhibits M1 macrophage polarization while promoting M2 polarization in LPS (Lipopolysaccharides)( HY-D1056 )-induced RAW264.7 cells. SIN 14 inhibits inflammatory mediator production (eg: NO , IL-6 , IL-1β and CCL2, inhibits production of ROS and down-regulates the expression of COX-2 and iNOS . SIN 14 can inhibit RA-related inflammatory edema in collagen-induced arthritis (ClA) mice.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Heme Oxygenase (HO) | Products > Signaling Pathways > Reactive Oxygen Species (ROS) | Products > Signaling Pathways > NO Synthase | Products > Signaling Pathways > COX | Products > Signaling Pathways > Interleukin Related

Product Information

• Catalog No.: HY-173518
• CAS No.: 3064262-80-9
• Molecular Formula: C19H18ClNO4
• Molecular Weight: 359.80
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source