KI-CDK9d-32

Overview

KI-CDK9d-32 is a highly selective and potent CDK9 PROTAC degrader ( DC 50 : 0.89 nM). KI-CDK9d-32 promotes the ubiquitination and degradation of CDK9 . KI-CDK9d-32 inhibits the MYC pathway and disrupts nucleolar homeostasis. KI-CDK9d-32 exhibits anticancer activity against acute lymphoblastic leukemia and pancreatic cancer . (Pink: CDK9 ligand ( HY-153718 ); Blue: Cereblon ligand ( HY-163233 ); Black: linker ( HY-W011657 )).

Application

Products | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Disease Areas > Pancreatic Cancer | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Acute Lymphoblastic Leukemia | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > CDK | Products > Signaling Pathways > c-Myc

Product Information

• Catalog No.: HY-173523
• CAS No.: 3054009-82-1
• Molecular Formula: C39H45N9O4
• Molecular Weight: 703.83
• Purity: 99.03%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (3.55 mM); Clear solution
• Availability: In-stock

Source

Original product source