SKLB-11A

Overview

SKLB-11A is a selective, orally active and allosteric SIRT3 ( sirtuin 3) agonist with a K d value of 4.7 μM. SKLB-11A is highly selective for other members of the SIRT family. SKLB-11A activates autophagy -related signaling pathways, prevents mitochondrial dysfunction, improves cardiac function in Doxorubicin ( HY-15142A )-induced cardiotoxicity and myocardial ischemia/reperfusion models.

Application

Products | Products > Disease Areas > Digestive System Inflammation | Products > Disease Areas > Cardiovascular Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Digestive System Disease | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Autophagy | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Sirtuin | Products > Signaling Pathways > Autophagy

Product Information

• Catalog No.: HY-173572
• CAS No.: 433953-86-7
• Molecular Formula: C19H15FN4O2
• Molecular Weight: 350.35
• Purity: 99.40%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source