T0080

Overview

T0080 is a central nervous system-penetrant FPR1 inhibitor. By functionally blocking the FPR1 signaling pathway, T0080 effectively reduces neutrophil infiltration into ischemic brain tissue and maintains the integrity of the blood-brain barrier. T0080 alleviates tPA -associated hemorrhagic transformation, inhibits demyelination responses and the expression of NOX2 . T0080 also possesses anti-apoptotic ( apoptosis ) and anti-inflammatory properties, thereby protecting myelin and reducing neurological deficits. T0080 is widely used in studies related to ischemic stroke complicated by hemorrhagic transformation after tPA thrombolysis, as well as multiple sclerosis.

Application

Products | Products > Disease Areas > Autoimmune Disease | Products > Disease Areas > Cerebrovascular Disease | Products > Disease Areas > Multiple Sclerosis | Products > Disease Areas > Ischemic Stroke | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Neurological Disease | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Formyl Peptide Receptor (FPR) | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-173591
• CAS No.: 2785323-68-2
• Molecular Formula: C24H22F3N3O3
• Molecular Weight: 457.44
• Purity: 99.94%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (5.47 mM); Clear solution
• Availability: In-stock

Source

Original product source