SJ11646

Overview

SJ11646 is a Dasatinib ( HY-10181 )-based LCK PROTAC degrader with a DC 50 of 0.00838 pM. SJ11646 has potent cytotoxicity against LCK-activated T-cell acute lymphoblastic leukemia (T-ALL) cells and primary leukemia samples with drastically prolonged suppression of LCK signaling, and induces T-ALL apoptosis . SJ11646 binds to 51 human kinases with a high affinity (particularly ABL1 , KIT, and DDR1 ). SJ11646 has superior antileukemic efficacy in T-ALL mice model. . Pink: LCK ligand ( HY-107447 ); Blue: CRBN ligase ligand ( HY-163169 ); Black: linker ( HY-76667 ) (Pink: Lck ligand ( HY-107447 ); Blue: Cereblon ligand ( HY-163169 ); Black: linker ( HY-76667 )).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Src | Products > Signaling Pathways > Discoidin Domain Receptor | Products > Signaling Pathways > Bcr-Abl | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-175281
• CAS No.: 2933135-82-9
• Molecular Formula: C36H40ClN9O5S
• Molecular Weight: 746.28
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source