Xanthine oxidase-IN-17 is a potent xanthine oxidase ( XOD ) inhibitor with an IC 50 of 298 nM and a K i of 167 nM. Xanthine oxidase-IN-17 decreases the formation of O ₂ ⁻ radical by inhibiting the catalytic activity of XOD to diminish the production of uric acid. Xanthine oxidase-IN-17 shows no cytotoxicity in AML-12 hepatocytes, while suppressing uric acid production. Xanthine oxidase-IN-17 can be used for the studies of hyperuricemia and subsequently to gout.
Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > Xanthine Oxidase
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