MRT-23227

Overview

MRT-23227 is a CRBN-recruiting molecular glue degrader targeting VAV1 . MRT-23227 binds to the tryptophan triad pocket of CRBN , forms a ternary complex with the SH3c domain of VAV1 , and induces proteasomal degradation of VAV1 through hydrogen-bond interactions between CRBN residues and the RT loop and side chains of VAV1 . MRT-23227 can be used in the research of T-cell leukemia and lymphoma.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > Molecular Glues

Product Information

• Catalog No.: HY-175453
• CAS No.: 3050683-03-6
• Molecular Formula: C22H20ClN3O3
• Molecular Weight: 409.87
• Purity: 99.45%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (6.10 mM); Suspended solution
• Availability: In-stock

Source

Original product source