FIP22

Overview

FIP22 is a potent and selective IRAK4 PROTAC degrader (HEK293T cells: DC 50 = 3.2 nM; THP-1 cells: DC 50 = 10.6 nM). FIP22 induces the ubiquitin-proteasome system by forming an IRAK4-FIP22-CRBN ternary complex ( EC 50 = 12.63 nM), thereby potently blocking IRAK4-mediated NF-κB and MAPK signaling pathways. FIP22 can be used for the study of atopic dermatitis. (Pink: IRAK4 Target protein ligand; Blue: Cereblon ligand ( HY-W087383 ); Black: linker ( HY-46871 )).

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > p38 MAPK | Products > Signaling Pathways > TNF Receptor | Products > Signaling Pathways > Interleukin Related | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > IRAK | Products > Signaling Pathways > NF-κB

Product Information

• Catalog No.: HY-175764
• CAS No.: 3091132-73-6
• Molecular Formula: C46H50N10O6
• Molecular Weight: 838.95
• Purity: 98.53%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source