Ferroptosis-IN-22

Overview

Ferroptosis-IN-22 is a selective ferroptosis inhibitor by targeting NCOA4 and disrupting its interaction with ferritin with an EC 50 of 520 nM and a K d of 0.78 μM. Ferroptosis-IN-22 has a strong inhibitory activity against ferroptosis induced by multiple ferroptosis inducers (RSL3 ( HY-100218A ), Erastin ( HY-15763 ), ML210 ( HY-100003 ), FIN56 ( HY-103087 )), but does not inhibit necrosis induced by H 2 O 2 or apoptosis induced by STS ( HY-15141 ). Ferroptosis-IN-22 effectively ameliorates Concanavalin A ( HY-P2149 )-induced acute liver injury. Ferroptosis-IN-22 can be used for the study of ferroptosis-related diseases.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Metabolic Disease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Ferroptosis

Product Information

• Catalog No.: HY-175869
• CAS No.: 3096878-87-1
• Molecular Formula: C27H23NO2
• Molecular Weight: 393.48
• Purity: 99.95%
• Storage: Store at room temperature, keep dry and cool. In solvent -80°C, 1 year , -20°C, 6 months
• Solubility: ≥ 2.5 mg/mL (6.35 mM); Clear solution
• Availability: In-stock

Source

Original product source