Solithromycin (CEM-101) is an orally bioavailable, effective antimicrobial agent, with IC 50 s for inhibition of cell viability, protein synthesis, and growth rate are 7.5 ng/mL, 40 ng/mL, and 125 ng/mL for Streptococcus pneumonia , Staphylococcus aureus , and Haemophilus influenzae , respectively. Solithromycin binds to the large 50S subunit of the ribosome and inhibits protein biosynthesis.
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