PROTAC HER2 degrader-1

Overview

PROTAC HER2 degrader-1 is a highly selective HER2 PROTAC degrader, with a DC 50 of 69 nM and a D max of 96%. PROTAC HER2 degrader-1 inhibits HER2 -positive cell proliferation and tumor growth through persistent HER2 degradation and potent inhibition of downstream pathways ( AKT and ERK ). PROTAC HER2 degrader-1 induces apoptosis in BT-474 cells. PROTAC HER2 degrader-1 can be used for research of HER2-positive cancers. (Pink: HER2 ligand ( HY-177009 ); Blue: Cereblon ligand ( HY-W023573 ); Black: linker).

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Breast Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > EGFR | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Akt | Products > Signaling Pathways > ERK | Products > Signaling Pathways > PROTACs

Product Information

• Catalog No.: HY-177008
• CAS No.: 2897640-93-4
• Molecular Formula: C49H55N11O7
• Molecular Weight: 910.03
• Purity: 99.98%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source