| Brivanib alaninate Basic information |
| Product Name: | Brivanib alaninate |
| Synonyms: | BMS-582664;BMS 582664;BMS582664;CS-362;L-Alanine (1R)-2-[[4-[(4-fluoro-2-Methyl-1H-indol-5-yloxy)]-5-Methyl-1H-pyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]isopropyl ester;(2R)-1-({4-[(4-fluoro-2-Methyl-1H-indol-5-yl)oxy]-5-Methylpyrrolo[2,1-f][1,2,4]triazin-6-yl}oxy)propan-2-yl (2S)-2-aMinopropanoate;Brivanib alaninate BMS-540215;(1R)-2-((4-((4-Fluoro-2-methyl-1H-indol-5-yl)oxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)oxy)-1-methylethyl L-alanine ester Brivanib alaninate (BMS-582664);Bms 582664;Bms582664 |
| CAS: | 649735-63-7 |
| MF: | C22H24FN5O4 |
| MW: | 441.46 |
| EINECS: | |
| Product Categories: | Inhibitors;Anti-cancer & immunity;Aromatics;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol File: | 649735-63-7.mol |
| Brivanib alaninate Chemical Properties |
| density | 1.42±0.1 g/cm3(Predicted) |
| solubility | ≥22.05 mg/mL in DMSO; insoluble in H2O; ≥10.03 mg/mL in EtOH |
| form | Yellow powder. |
| pka | 16.08±0.30(Predicted) |
| Safety Information |
| MSDS Information |
| Brivanib alaninate Usage And Synthesis |
| Uses | A novel prodrug of dual vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1 kinase inhibitor. |
| Uses | BMS-582664 is an oral VEGFR/FGFR inhibitor for VEGFR2, Flk1, VEGFR1 and FGFR1 with IC50 of 25 nM, 89 nM, 380 nM and 148 nM, respectively. |
| Brivanib alaninate Preparation Products And Raw materials |
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