2-Hydroxychalcone

CAS No.：644-78-0

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2-Hydroxychalcone Basic information

Product Name:	2-Hydroxychalcone
Synonyms:	BENZYLIDENE-2-HYDROXYACETOPHENONE;(E)-3-(2-HYDROXYPHENYL)-1-PHENYLPROP-2-EN-1-ONE;HYDROXYCHALCONE, 2-;2-HYDROXYCHALCONE;2-HYDROXYBENZYLIDENE ACETOPHENONE;2-(2-HYDROXYBENZAL)ACETOPHENONE;2-(2-HYDROXYBENZYLIDENE)ACETOPHENONE;(2-Hydroxybenzylidene)acetophenone~3-(2-Hydroxyphenyl)-1-phenyl-2-propen-1-one
CAS:	644-78-0
MF:	C15H12O2
MW:	224.25
EINECS:	211-422-1
Product Categories:	Biochemistry;Building Blocks for Liquid Crystals;Chalcones;Chalcones, etc. (Building Blocks for Liquid Crystals);Flavonoids;Functional Materials
Mol File:	644-78-0.mol

2-Hydroxychalcone Chemical Properties

Melting point	144-150 °C(lit.)
Boiling point	396.3±34.0 °C(Predicted)
density	1.191±0.06 g/cm3(Predicted)
pka	9.26±0.35(Predicted)
BRN	2049134
CAS DataBase Reference	644-78-0(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	3
HS Code	29147000

MSDS Information

Provider	Language
SigmaAldrich	English
ACROS	English
ALFA	English

2-Hydroxychalcone Usage And Synthesis

Description	2-hydroxychalcone, a natural flavonoid, is a potent antioxidant, inhibiting lipid peroxidation. 2-Hydroxychalcone induces apoptosis by Bcl-2 downregulation. 2-Hydroxychalcone inhibits the activation of NF-kB.
in vitro	2-Hydroxychalcone inhibits invasion of triple negative breast cancer cells.2-hydroxychalcone inhibits the adhesion of peripheral neutrophils to the endothelial cell monolayers by inhibiting the expression of ICAM-1, VCAM-1, and E-selectin in a concentration-dependent manner.
References	[1]. Sun Young Kim, et al. 2-Hydroxychalcone and Xanthohumol Inhibit Invasion of Triple Negative Breast Cancer Cells. Chem Biol Interact. 2013 May 25;203(3):565-72. [2]. B Madan, et al. 2'-hydroxychalcone Inhibits Nuclear factor-kappaB and Blocks Tumor Necrosis Factor-Alpha- And Lipopolysaccharide-Induced Adhesion of Neutrophils to Human Umbilical Vein Endothelial Cells. Mol Pharmacol. 2000 Sep;58(3):526-34. [3]. BABITA MADAN, et al. 2-Hydroxychalcone Inhibits Nuclear Factor-kB and Blocks Tumor Necrosis Factor-a- and Lipopolysaccharide-Induced Adhesion of Neutrophils to Human Umbilical Vein Endothelial Cells. Mol Pharmacol 58:526–534, 2000.

2-Hydroxychalcone Preparation Products And Raw materials

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