UAWJ9-36-3 is a M pro and cathepsin L ( IC 50 : 1.81 μM) inhibitor. UAWJ9-36-3 shows potent binding and enzymatic inhibition against the M pro s from SARS-CoV-2, SARS-CoV , MERS-CoV, HCoV-OC43, HCoV-NL63, HCoV-229E, and HCoV-HKU1. UAWJ9-36-3 demonstrates broad-spectrum antiviral activity against not only SARS-CoV-2 , but also the common human coronaviruses HCoV-OC43 , HCoV-NL63 , and HCoV-229E .
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