MH44 is an efficient inhibitor targeting the SARS-CoV-2 nsp14 N7-methyltransferase ( N7-MTase ) with an IC 50 of 19 nM. MH44 exhibits moderate antiviral effects in SARS-CoV-2-infected A549-hACE2 cells and shows certain cytotoxicity at higher concentrations. MH44 can be used in the research on anti-SARS-CoV-2.
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