PROTAC DAPK1 Degrader-1

Overview

PROTAC DAPK1 Degrader-1 (Compound CP1) is a DAPK1 PROTAC degrader with a DC 50 of 119.6 nM. PROTAC DAPK1 Degrader-1 significantly increased the MDM2 protein level. PROTAC DAPK1 Degrader-1 significantly reduced the levels of cleaved caspase-3 and cleaved PARP in a cell apoptosis model induced by the neurotoxin ceramide, indicating that it effectively inhibits neuronal apoptosis by degrading DAPK1. PROTAC DAPK1 Degrader-1 can be used to study neurological diseases such as cerebral ischemia and traumatic brain injury (pink: DAPK1 ligand ( HY-179071 ); blue: CRBN ligand ( HY-10984 ); black: linker ( HY-40171 )). (Pink: DAPK ligand ( HY-179071 ); Blue: Cereblon ligand ( HY-10984 ); Black: linker ( HY-40171 )).

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > DAPK

Product Information

• Catalog No.: HY-179055
• CAS No.: 3063030-38-3
• Molecular Formula: C30H27N9O7S
• Molecular Weight: 657.66
• Purity: 96.70%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Availability: In-stock

Source

Original product source