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| Product Name: | Verbascoside | | Synonyms: | glucopyranoside,2-(3,4-dihydroxyphenyl)ethyl3-o-(6-deoxy-alpha-l-mannopyranos;ACTEOSIDE :B-D-GLUCOPYRANOSIDE, 2-(3,4-DIHYDROXYPHENYL)ETHYL 3-O-(6-DEOXY-A-L-MANNOPYRANOSYL)-,4-[3-(3,4-DIHYDROXYPHENYL)-2-PROPENOATE],(E)-,;Acetoside;Extract from Verbena minutiflora (B864379);[(2R,3R,4R,5R,6R)-6-[2-(3,4-Dihydroxyphenyl)ethoxy]-5-hydroxy-2-(hydroxymethyl)-4-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl] (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate;VERBASCOSIDE WITH HPLC;2-(3,4-Dihydroxyphenyl)ethyl 3-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside 4-[(E)-3-(3,4-dihydroxyphenyl)propenoate];3,4-Dihydroxyphenethyl alcohol acteoside | | CAS: | 61276-17-3 | | MF: | C29H36O15 | | MW: | 624.59 | | EINECS: | | Product Categories: | reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Miscellaneous Natural Products;chemical reagent;pharmaceutical intermediate;phytochemical | | Mol File: | 61276-17-3.mol |
| Verbascoside Chemical Properties |
| Melting point | 232℃ | | Boiling point | 908.8±65.0 °C(Predicted) | | density | 1.60±0.1 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | solubility | DMSO (Slightly), Ethyl Acetate (Very Slightly), Methanol (Slightly) | | pka | 9.31±0.10(Predicted) | | form | Solid | | color | White to Pale Yellow | | Stability: | Hygroscopic | | InChIKey | FBSKJMQYURKNSU-ZLSOWSIRSA-N | | CAS DataBase Reference | 61276-17-3(CAS DataBase Reference) |
| Safety Statements | 24/25 | | WGK Germany | 2 | | RTECS | LZ5786000 | | HS Code | 29389090 | | Toxicity | LD50 oral in rat: > 5gm/kg |
| Verbascoside Usage And Synthesis |
| Description | Verbascoside is isolated from Lantana camara, acts as an ATP-competitive inhibitor of PKC, with an IC50 of 25 µM, and has antitumor, anti-inflammatory and antineuropathic pain activity.
| | Natural occurrences | Verbascoside can be found in species in all the families of the order Lamiales (syn. Scrophulariales). Only two examples are known from outside the order,in the clade Asterids.
| | Mechanism of action | It is known, that amyloid fibrils accumulation in cerebral can easily lead to neurodegenerative disorders. Acteoside has been reported to inhibit Aβ42 aggregation by activating nuclear translocation of the transcription factor NF-E2-related factor 2 (Nrf2), increasing heme oxygenase-1 (HO-1) expression. It has also been shown that acteoside could decrease nitric oxide synthase (NOS) activity and caspase-3 expression.
| | Chemical Properties | White solid | | Uses | Verbascoside is an agent producing effects on anti-GBM nephritis in rats. Effective agent against glomerulonephritis. Phenolic anti-oxidant agent. | | Enzyme inhibitor | This plant glycoside and antioxidant (FW = 624.60 g/mol; CAS 61276-173), also known as verbascoside, inhibits TNFa-mediated apoptosis in LPSstimulated macrophages as well as 1-methyl-4-phenylpyridiniuminduced apoptosis in cerebellar granule neurons. It also inhibits proliferation of human promyelocytic HL-60 leukemia cells by inducing cell cycle arrest at the G0/G1 phase, followed by differentiation into monocytes. Acteoside inhibits PMA-induced invasion and migration of human fibrosarcoma cells by Ca2+-dependent CaMK/ERK and JNK/NFκB-signaling pathways. Acteoside thus shows the potential as antimetastatic agent. Another intriguing finding is that acteoside inhibits amyloid-β aggregation. Target(s): aldose reductase; protein kinase C; integrase, HIV-1; peptidyl-dipeptidase A, or angiotensin-converting enzyme; tyrosinase, or monophenol monooxygenase; 5-lipoxygenase, or arachidonate 5-lipoxygenase. |
| Verbascoside Preparation Products And Raw materials |
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