SCPI-3 is a potent and competitive mosquito sterol carrier protein-2 ( SCP-2 ) inhibitor ( AeSCP-2 IC 50 = 0.159 µM; AeSCP-x IC 50 = 0.285 µM). SCPI-3 exhibits physiological effects on cholesterol metabolism in cultured insect cells ( IC 50 of 3.09 µM in Aag-2 cells). SCPI-3 shows insecticidal activity against Aedes aegypti with a LD 50 of 12.3 µM.
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