BI-9627 hydrochloride

Overview

BI-9627 hydrochloride is a potent sodium-hydrogen exchanger isoform 1 ( NHE1 ) inhibitor ( IC 50 = 6 and 31 nM in intracellular pH recovery (pH i ) and human platelet swelling assays). BI-9627 hydrochloride displays >30-fold selectivity against NHE2 and with no measurable inhibitory activity against the NHE3 isoform. BI-9627 hydrochloride decreases autophagy in HTR-8/SVneo cells. BI-9627 hydrochloride can significantly reduce the pH i of human sperm and partially reverse the effect of DMA. BI-9627 hydrochloride prolongs Ca 2+ recovery time in KO hiPSC-CMs. BI-9627 hydrochloride shows low DDI (agent-agent interaction) potential, excellent pharmacokinetics in rat and dog, and remarkably potent activity in the isolated heart model of ischemia-reperfusion injury.

Application

Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Cardiovascular Disease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Autophagy | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Na+/H+ Exchanger (NHE) | Products > Signaling Pathways > Autophagy

Product Information

• Catalog No.: HY-18071A
• CAS No.: 1422252-46-7
• Molecular Formula: C16H20ClF3N4O2
• Molecular Weight: 392.80
• Purity: 98.01%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: ≥ 2.5 mg/mL (6.36 mM); Clear solution
• Availability: In-stock

Source

Original product source