SR-5037

Overview

SR-5037 is an orally active CDK12 ( IC 50 = 31 nM)/ CDK13 inhibitor and CycK ( DC 50 = 30 nM; D max > 98%) molecular glue degrader. SR-5037 inhibits the enzymatic activity of CDK12 /CycK and CDK13 /CycK complexes. SR-5037 promotes the recruitment of DDB1 to the CDK12 /CycK complex, thereby triggering proteasome-mediated CycK degradation. SR-5037 degrades active CycK in mouse models of triple-negative breast cancer . SR-5037 can be used in the research of cancers such as triple-negative breast cancer .

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Breast Cancer | Products > Disease Areas > Triple-Negative Breast Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Signaling Pathways > Molecular Glues | Products > Signaling Pathways > CDK

Product Information

• Catalog No.: HY-181405
• CAS No.: 2387704-74-5
• Molecular Formula: C21H18Cl2F2N10O
• Molecular Weight: 535.34
• Purity: 99.58%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source