JNK3-IN-10

Overview

JNK3-IN-10 is a blood-brain barrier-impermeable JNK3 inhibitor ( IC 50 =0.257 nM) with over 400-fold selectivity over JNK1 . JNK3-IN-10 blocks the JNK3 -mediated signaling pathway downstream of TGF-β 1 , inhibits TGF-β 1 -induced phosphorylation of c-Jun , reduces the expression of pro-fibrotic markers, and restores the expression of the epithelial protein E-cadherin . JNK3-IN-10 exhibits low cytotoxicity, anti-fibrotic, cytoprotective and renoprotective effects, and alleviates albuminuria, glomerulosclerosis and podocyte foot process fusion. JNK3-IN-10 can be used for the research of chronic kidney disease, glomerulosclerosis and adriamycin-induced nephropathy.

Application

Products | Products > Disease Areas > Renal Disease | Products > Disease Areas > Chronic Kidney Disease | Products > Disease Areas > Urogenital Disease | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > TGF-beta/Smad | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > Cytoskeleton | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > JNK | Products > Signaling Pathways > TGF-beta/Smad | Products > Signaling Pathways > Cadherin

Product Information

• Catalog No.: HY-181556
• CAS No.: 3085181-00-3
• Molecular Formula: C24H24Cl2N8O2S
• Molecular Weight: 559.47
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source