Cathepsin D degrader 1

Overview

Anti-hepatic fibrosis agent 3 is an orally active anti-hepatic fibrosis compound targeting Cathepsin D . Anti-hepatic fibrosis agent 3 shows an IC 50 of 53.18 μM against COL1A1-promoter and a K d of 8.86 μM for binding to Cathepsin D . Anti-hepatic fibrosis agent 3 directly binds to and promotes the degradation of Cathepsin D , with no significant effect on Cathepsin B or Cathepsin L . Anti-hepatic fibrosis agent 3 inhibits hepatic stellate cell activation and reduces extracellular matrix deposition and inflammatory cytokine expression. Anti-hepatic fibrosis agent 3 exhibits remarkable anti-fibrotic activity in rat BDL and mouse CDAHFD-induced hepatic fibrosis models. Anti-hepatic fibrosis agent 3 can be used for the study of hepatic fibrosis.

Application

Products | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Liver Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > Cathepsin

Product Information

• Catalog No.: HY-181655
• CAS No.: 3127060-85-6
• Molecular Formula: C22H28N2O3
• Molecular Weight: 368.47
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source