PDE4/5-IN-1 is a selective phosphodiesterase 4/5 ( PDE4/5 ) dual inhibitor. PDE4/5-IN-1 functionally inhibits PDE5 , PDE4B2 , and PDE4D2 activity. PDE4/5-IN-1 relaxes isolated rat prostate tissue, enhances nitric oxide-induced relaxation in isolated rat prostate tissue, and reduces alpha-1 adrenoceptor-mediated contractile responses in isolated rat prostate tissue. PDE4/5-IN-1 inhibits proliferation of human hyperplastic prostate cells. PDE4/5-IN-1 can be used for the research of benign prostatic hyperplasia.
Products | Products > Disease Areas > Urogenital Disease | Products > Disease Areas > Male Reproductive System Disease | Products > Disease Areas > Prostatic Hyperplasia | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Endocrinology | Products > Signaling Pathways > Phosphodiesterase (PDE)
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