PS1097 is a broad-spectrum antiviral inhibitor with a BVDV RdRp IC 50 of 0.64 μM. PS1097 selectively reduces RTN3 protein levels, causes partial RTN3 mRNA reduction, and leaves other endoplasmic reticulum-resident proteins unaffected. PS1097 inhibits replication of Zika virus and multiple viruses that use the endoplasmic reticulum as a replication hub. PS1097 inhibits BVDV RdRp enzymatic activity and exerts activity against Bovine Viral Diarrhea Virus. PS1097 can be used for the research of zika virus infection , usutu virus infection , west nile virus infection , COVID-19, coxsackie b virus 5 infection , chikungunya virus infection , vaccinia virus infection .
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