CGS 27023A free base is a non-peptidic and orally active MMP inhibitor with the K i values of 43, 33, 20 and 8 nM for MMP-3 , MMP-1 , MMP-2 amd MMP-9 , respectively. CGS 27023A free base prevents cartilage degradation in stromelysin-induced rabbit cartilage degradation model. CGS 27023A free base can be used for study of arthritis.
Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > MMP
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