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| N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine Basic information |
| Product Name: | N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine | | Synonyms: | N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine;WZ 811;N,N'-(1,4-PHENYLENEBIS(METHYLENE))DIPYRIDIN-2-AMINE;N,N'-Di-2-pyridinyl-1,4-benzenedimethanamine;N,N'-(1,4-phenylenebis(methylene))bis(pyridin-2-amine);1,4-Benzenedimethanamine, N1,N4-di-2-pyridinyl-;N1,N4-di-2-pyridinyl-1,4-benzenedimethanamine WZ811;WZ 811 N,N'-Di-2-pyridinyl-1,4-benzenedimethanamine | | CAS: | 55778-02-4 | | MF: | C18H18N4 | | MW: | 290.36 | | EINECS: | 200-256-5 | | Product Categories: | Inhibitors | | Mol File: | 55778-02-4.mol |
| N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine Chemical Properties |
| Melting point | 192-194℃ (methanol ) | | Boiling point | 493.2±35.0 °C(Predicted) | | density | 1.229±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | | solubility | DMSO: ≥7mg/mL | | form | powder | | pka | 6.55±0.10(Predicted) | | color | white to tan |
| Hazard Codes | Xn | | Risk Statements | 22-36/37/38 | | Safety Statements | 26 | | WGK Germany | 3 |
| N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine Usage And Synthesis |
| Description | The CXC chemokine receptor-4 (CXCR4) is a G protein-coupled receptor that is specific for stromal cell-derived factor-1 (SDF-1/ CXCL12). Activation of CXCR4 promotes homing of hematopoietic stem cells, chemotaxis and quiescence of lymphocytes, and growth and metastasis of certain cancer cell types. Moreover, CXCR4 on CD4+ T-cells is used by CXCR4-selective HIV forms as a gateway for T-cell infection. WZ811 is a potent inhibitor of binding of an SDF-1 peptide mimic to CXCR4 (EC50 = 0.3 nM). It prevents SDF-1/CXCL12-mediated modulation of cAMP (EC50 = 1.2 nM) in cells and blocks SDF-1-induced Matrigel™ invasion by MDA-MB-231 human breast adenocarcinoma cells (EC50 = 5.2 nM). The effectiveness of WZ811 in animals remains to be elucidated. | | Uses | N1,N4-di-2-Pyridinyl-1,4-benzenedimethanamine acts as an inhibitor for the chemokine receptor CXCR4. | | references | [1] zhan w, liang z, zhu a, et al. discovery of small molecule cxcr4 antagonists. journal of medicinal chemistry, 2007, 50(23): 5655-5664.[2] choi w t, duggineni s, xu y, et al. drug discovery research targeting the cxc chemokine receptor 4 (cxcr4). journal of medicinal chemistry, 2011, 55(3): 977-994. |
| N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine Preparation Products And Raw materials |
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