Solabegron-d 8 (GW 427353-d 8 ) is deuterium labeled Solabegron. Solabegron (GW 427353) is a selective β 3 -adrenergic receptor agonist, stimulating cAMP accumulation in Chinese hamster ovary cells expressing the human β 3 -AR, with an EC 50 value of 22 nM. Solabegron (GW 427353) is being developed for the treatment of overactive bladder and irritable bowel syndrome.
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