AG-7404 is an orally active, irreversible inhibitor of the picornavirus 3C protease . AG-7404 blocks the processing of viral polyproteins, thereby inhibiting viral replication. AG-7404 has synergistic antiviral activity with capsid inhibitors such as V-073 ( HY-104074 ) or BTA798 ( HY-106254 ) and is effective against V-073-resistant variants. AG-7404 is used in the study of enterovirus infections such as poliovirus.
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