AR-102 has inhibitory activity towards Staphylococcus aureus . AR-102 exhibits a competitive potent inhibition of the F98Y mutant DHFR ( K i = 0.22 nM). AR-102 has been determined as ternary complex with NADPH in both wild-type S. aureus DHFR and the TMP-resistant F98Y mutant enzyme.
Products | Products > Disease Areas > Infection | Products > Signaling Pathways > Anti-infection | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Infection | Products > Signaling Pathways > Bacterial | Products > Signaling Pathways > Dihydrofolate reductase (DHFR)
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