SU-4313 is a potent protein tyrosine kinases (PTKs) modulator with IC 50 s of 14.5 μM, 18.8 μM, 11 μM, 16.9 μM, 8.0 μM for PDGFR , FLK-1, EGFR , HER2 Kinase and IGF-1R , respectively. SU-4313 has the potential for modulating tyrosine kinase signal transduction in order to regulate abnormal cell proliferation.
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