L-KAWAIN

CAS No.：500-64-1

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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L-KAWAIN Basic information

Product Name:	L-KAWAIN
Synonyms:	6-dihydro-4-methoxy-6-styryl-(r)-2h-pyran-2-on;gonosan;(R)-(+)-Kavain;[R-(E)]-5,6-dihydro-4-methoxy-6-styryl-2H-pyran-2-one;5,6-Dihydro-4-methoxy-6-styryl-2-pyron;(6R)-5,6-Dihydro-4-methoxy-6-[(E)-2-phenylethenyl]-2H-pyran-2-one;(R)-5,6-Dihydro-4-methoxy-6-[(E)-2-phenylethenyl]-2H-pyran-2-one;2H-Pyran-2-one, 5,6-dihydro-4-methoxy-6-(2-phenylethenyl)-, [R-(E)]-
CAS:	500-64-1
MF:	C14H14O3
MW:	230.26
EINECS:	207-907-2
Product Categories:	Coumarins;Miscellaneous Natural Products
Mol File:	500-64-1.mol

L-KAWAIN Chemical Properties

Melting point	142-148℃
alpha	D20 +105° (abs alc)
Boiling point	bp0.1 195-197°
density	1.1914 (rough estimate)
refractive index	1.5557 (estimate)
storage temp.	Amber Vial, -20°C Freezer, Under inert atmosphere
solubility	Chloroform (Slightly), Ethanol (Slightly, Sonicated), Methanol (Slightly)
form	Solid
color	White to Light Yellow
Stability:	Light Sensitive

Safety Information

Hazard Codes	Xn
Risk Statements	22
HS Code	2932202000

MSDS Information

L-KAWAIN Usage And Synthesis

Originator	Largon,Klinge
Uses	Kawain is a plant extract that shows antioxidant activity through cyclooxygenase enzyme inhibition. May also be active in tumor suppression and apoptotic induction.
Manufacturing Process	To 1170 g ethyl acetoacetate at 100-110°C was added a little at time 1605 g bromosuccinimide. After cooling to the mixture was added 300 ml of carbon tetrachloride. From the mixture was isolated ethyl ester of bromoacetoacetic acid which was distilled at 105-125°C/18 mm; yield 67%.By condensation of the mixture 1400 g ethyl ester of bromoacetoacetic acid, 700 g bromosuccineimide, 500 ml benzene and 350 mg zinc was prepared (R)-5,6-dihydro-4-methoxy-6-styryl-2H-pyran-2-one; melting point 157°C, yield 60-70%.
Therapeutic Function	Anesthetic; Tranquilizer

L-KAWAIN Preparation Products And Raw materials

Raw materials

N-Bromosuccinimide-->ZINC-->Ethyl acetoacetate

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