MAC-5576 is a SARS-CoV-2 3CL protease inhibitor, with an IC 50 of 81 nM. MAC-5576 also inhibits 3CLpro ( IC 50 =0.5 μM), HAV 3Cpro ( IC 50 =0.5 μM), and thrombin ( IC 50 =13 μM).
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