Safinamide-d 4 -1 is deuterium labeled Safinamide. Safinamide is a potent, selective, and reversible monoamine oxidase B ( MAO-B ) inhibitor ( IC 50 =0.098 μM) over MAO-A ( IC 50 =580 μM). Safinamide also blocks sodium channels and modulates glutamate (Glu) release, showing a greater affinity at depolarized ( IC 50 =8?μM) than at resting ( IC 50 =262?μM) potentials. Safinamide has neuroprotective and neurorescuing effects and can be used for the study of parkinson disease, ischemia stroke etc.al.
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