Fosamprenavir -d 4 is the Deuterium-labeled Fosamprenavir ( HY-78726 ). Fosamprenavir is an orally active inhibitor targeting HIV-1 protease and is a prodrug of Amprenavir ( HY-17430 ). Fosamprenavir is hydrolyzed into Amprenavir (VX-478) by cell phosphatases in the intestinal epithelium. Amprenavir binds to the active site of HIV-1 protease, preventing the processing of viral gag and gag-pol polyprotein precursors, thereby inhibiting the formation of mature infectious virus particles and exerting anti-HIV-1 infection activity. Fosamprenavir can be used for the study of human immunodeficiency virus ( HIV-1 ) infection .
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