Ondansetron (GR 38032; SN 307) is a highly selective 5-HT 3 receptor antagonist with an IC 50 value of 103 pM. Ondansetron exerts its antiemetic effect by antagonizing 5-HT receptors located in localized neurons in the peripheral and central nervous systems. Ondansetron can inhibit nausea and vomiting induced by chemotherapy and radiotherapy.
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