Zonisamide (AD 810) is an orally active carbonic anhydrase inhibitor, with K i s of 35.2 and 20.6 nM for hCA II and hCA V , respectively. Zonisamide exerts neuroprotective effects through anti- apoptosis and upregulating MnSOD levels. Zonisamide also increases the expression of Hrd1 , thereby improving cardiac function in AAC rats. Zonisamide can be used in studies of seizure, parkinson’s disease and cardiac hypertrophy.
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