Milnacipran (hydrochloride) (Standard) is the analytical standard of Milnacipran hydrochloride ( HY-B0168A ). This product is intended for research and analytical applications. Milnacipran hydrochloride is an orally active Serotonin ( HY-B1473A ) and Norepinephrine ( HY-13715 ) reuptake inhibitor. Milnacipran hydrochloride inhibits monoamine transporters, especially the norepinephrine transporter and the serotonin transporter ( K i values of 31 and 8.5 nM, respectively). Milnacipran hydrochloride inhibits pERK1/2 activation. Milnacipran hydrochloride has antidepressant, anxiolytic and analgesic properties. Milnacipran hydrochloride inhibits biting behavior in mice. Milnacipran hydrochloride can be used in the study of major depressive disorder, anxiety disorders, and neuropathic pain (e.g., fibromyalgia).
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