Mirtazapine (Org3770) is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent. Mirtazapine is also a 5-HT 2 , 5-HT 3 , histamine H1 receptor and α2-adrenoceptor antagonist with pK i values of 8.05, 8.1, 9.3 and 6.95, respectively.
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