Clorsulon (L631529; MK401) is an orally active flukicidal agent . Clorsulon inhibits glycolysis, the primary energy production pathway in flukes. Clorsulon is also a competitive inhibitor of 3-phosphoglycolate and ATP, inhibiting glucose utilization and acetate and propionate formation by mature Fasciola hepatica in vitro. Clorsulon can be used in studies of liver fluke ( Fasciola hepatica and Fasciola gigantica) infection in calves and sheep.
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