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| BLASTICIDIN S HYDROCHLORIDE Basic information |
| Product Name: | BLASTICIDIN S HYDROCHLORIDE | | Synonyms: | BLASTICIDINE S HYDROCHLORIDE;BLASTICIDIN S HCL;BLASTICIDIN S HYDROCHLORIDE;BLASTICIDIN S, HYDROCHLORIDE, STREPTOMYCES GRISEOCHROMOGENES;Blasticidine S hydrochloride,Blasticidin S;(S)-4-[[3-amino-5-[(aminoiminomethyl)methylamino]-1-oxopentyl]amino]-1-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1,2,3,4-tetradeoxy-β-D-erythro-Hex-2-enopyranuronic acid,monohydrochloride;Blasticidine S HCl;Blasticidine S hydrochloride solution | | CAS: | 3513-03-9 | | MF: | C17H27ClN8O5 | | MW: | 458.9 | | EINECS: | | Product Categories: | Inhibitors;antibiotic | | Mol File: | 3513-03-9.mol |
| BLASTICIDIN S HYDROCHLORIDE Chemical Properties |
| Melting point | 224-225 °C (decomp) | | storage temp. | −20°C | | solubility | Soluble in Water (greater than 25 mg/ml) | | form | Liquid | | color | White | | Water Solubility | Soluble in water. Insoluble in organic solvents. | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month. |
| Hazard Codes | T+ | | Risk Statements | 28 | | Safety Statements | 28-36/37-45 | | RIDADR | UN 2811 6.1/PG 2 | | WGK Germany | 3 | | F | 1-10 | | HazardClass | 6.1 | | HS Code | 29349990 |
| BLASTICIDIN S HYDROCHLORIDE Usage And Synthesis |
| Description | Blasticidin S HCl (3513-03-9) is a peptidyl nucleoside antibiotic inhibiting protein synthesis in bacteria and eukaryotes.1?Inhibits translation by trapping deformed tRNA on the ribosome.1?The ABC-type transporter NppA1A2BCD is required for uptake of blasticidin S and other peptidyl nucleoside antibiotics in?Pseudomonas aeruginosa?PA14.2?Selection agent for bis, bsr and bsd transformed cells.3,4 | | Chemical Properties | White powder | | Uses | Inhibits protein synthesis and induces apoptosis. Used to study protein synthesis at the level of peptide bond formation. | | Uses | Blasticidin S hydrochloride is used to inhibit protein synthesis in prokaryotic and eukaryotic organisms. It also induces apoptosis. | | Uses | Blasticidin S hydrochloride is a salt of blasticidin S, an amphoteric nucleoside produced by several species of Streptomyces, first reported in the late 1950s. Blasticidin S hydrochloride was originally isolated fby acetone precipitation. For historical reasons only the salt has been routinely available to researchers. Both the salt and free base are freely water soluble. Blasticidin S is an antifungal agent with particularly potent activity against the rice pathogen, Piricularia oryzae, for which it was used commercially for some time in Japan. Blasticidin S inhibits protein synthesis and is active against bacteria, tumour cell lines and nematodes. More recently, blasticidin S has been used as a marker for strain manipulations. | | General Description | Nucleoside antibiotic that specifically inhibits protein synthesis in both prokaryotes and eukaryotes. Suitable for selection of cells carrying plasmids conferring blasticidin resistance. Blasticidin resistance is conferred by the blasticidin S deaminase gene (bsr) that converts blastisidin S to a nontoxic deaminohydroxy derivative. | | References | 1) Svidritskiy?et al., (2013),?Blasticidin S inhibits translation by trapping deformed tRNA on the ribosome;?Proc. Natl. Acad. Sci. USA?110?12283
2) Pletzer?et al.?(2015),?The Pseudomonas aeruginosa PA14 ABC Transporter NppA1A2BCD is Required for Uptake of Peptidyl Nucleoside Antibiotics; J. Bacteriol.?197?2217
3) Asada?et al.?(2015),?Transfection of Babesia bovis by Double Selection with WR99210 and Blasticidin-S and Its Application for Functional Analysis of Thioredoxin Peroxidase-1; PLoS One,?10?e0125993
4) Garg and Qadri (2010),?Hemoglobin transforms anti-inflammatory Salmonella typhi virulence polysaccharide into a TLR-2 agonist; J. Immunol.?184?5980 |
| BLASTICIDIN S HYDROCHLORIDE Preparation Products And Raw materials |
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