Thonzonium bromide is an antibacterial agent that is structurally similar to Farnesol ( HY-Y0248A ). Thonzonium bromide is also a monocationic surface-active agent, which inhibits RANKL-induced osteoclast formation and bone resorption in vitro and prevents LPS-induced bone loss in vivo. Thonzonium bromide inhibits proton transport in a dose-dependent manner (EC 50 =69 μM).
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