Imidapril-d 3 (hydrochloride)

Overview

Imidapril-d 3 hydrochloride (TA-6366-d 3 ) is the deuterium labeled Imidapril hydrochloride. Imidapril hydrochloride (TA-6366) is an orally active dual inhibitor of angiotensin-converting enzyme ( ACE ) and MMP-9 . Imidapril hydrochloride inhibits lipopolysaccharide-induced phosphorylation of c-Jun , MKK4 and JNK in monocytes, and downregulates the production of specific inflammatory factors such as TNF-α and IP-10 , thereby exerting anti-inflammatory activity. Imidapril hydrochloride also effectively ameliorates mesangial expansion and reduces urinary albumin excretion by inhibiting angiotensin AngII production, lowering glomerular pressure and oxidative stress, thus delaying disease progression. Imidapril hydrochloride can also directly bind to the active site of MMP-9 to inhibit gelatinase activity, and suppress the enlargement of cerebral aneurysms without altering systemic blood pressure. Imidapril hydrochloride is widely applicable to related studies on autoimmune glomerulonephritis, diabetic nephropathy, cerebral aneurysms and other conditions.

Application

Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Signaling Pathways > Others | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Isotope-Labeled Compounds | Products > Signaling Pathways > Angiotensin-converting Enzyme (ACE) | Products > Signaling Pathways > MMP | Products > Signaling Pathways > JNK

Product Information

• Catalog No.: HY-B1451S
• CAS No.: 1356017-30-5
• Molecular Formula: C20H25D3ClN3O6
• Molecular Weight: 444.92
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source