Meldonium (MET-88) functions as a cardioprotective agent by cpmpetetively inhibiting γ-butyrobetaine hydroxylase (BBOX) and carnitine/organic cation transporter type 2 (OCTN2) . Meldonium exhibits IC 50 values of 34-62 μM for human recombinant BBOX and an EC 50 of 21 μM for human OCTN2. Meldonium is a fatty acid oxidation inhibitor.
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