Malachite green hemioxalate (MCCK1) is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions. Malachite green hemioxalate has antibacterial activity, which is attributed to inhibition of intracellular enzymes , insertion into DNA and/or interaction with cell membranes. Malachite green hemioxalate is also a potent and selective inhibitor of IKBKE , and inhibits its downstream targets such as IκBα , p65 and IRF3 . Malachite green hemioxalate exhibits antitumor activity in vitro and in vivo.
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