THAM acetate is a low-toxicity amino alcohol buffer, a CO 2 -consuming proton acceptor that buffers carbon dioxide and acid both in vitro and in vivo. THAM acetate binds protons to form bicarbonate, reduces PaCO 2 , and induces intracellular alkalization, thereby ameliorating hypercapnia-induced elevation of pulmonary blood vessels and pulmonary arterial pressure. THAM acetate may cause PaCO 2 rebound, hypoglycemia, and respiratory depression. THAM acetate removes amniotic epithelium and preserves the basement membrane, but depletes extracellular matrix and reduces the adhesion rate of limbal epithelial cells. THAM acetate can act as a CO 2 carrier to enhance the productivity and carbon utilization rate of Scenedesmus obliquus . THAM acetate is a key component of buffer solutions used in various biological, cell culture , biochemical, and molecular biology applications.
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