Omeprazole sulfone

Overview

Omeprazole sulfone (Omeprazole sulphone) is one of the major circulating metabolites of Omeprazole ( HY-B0113 ) in vivo, and belongs to class 4 non-mutagenic impurities. Omeprazole sulfone does not bind to the aryl hydrocarbon receptor ( AhR ), nor does it induce the expression of CYP1A1 or CYP1A2 . However, Omeprazole sulfone promotes the migration of gastric epithelial cells under basal conditions and reverses the inhibitory effect of Indomethacin ( HY-14397 ) on cell migration. Omeprazole sulfone does not promote cell proliferation, nor does it upregulate COX-2 expression or activate signaling pathways such as ERK , P38 MAPK and PI3K . Omeprazole sulfone maintains basal ulcer healing under non-acid-dependent conditions and can be used in studies related to gastric ulcer repair.

Application

Products | Products > Disease Areas > Gastric Ulcer | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Gastric Disease | Products > Disease Areas > Peptic Ulcer Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Drug Metabolite | Products > Signaling Pathways > Cytochrome P450 | Products > Signaling Pathways > Aryl Hydrocarbon Receptor

Product Information

• Catalog No.: HY-G0007
• CAS No.: 88546-55-8
• Molecular Formula: C17H19N3O4S
• Molecular Weight: 361.42
• Purity: 99.23%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.08 mg/mL (5.76 mM); Clear solution
• Availability: In-stock

Source

Original product source