N-Desmethyl imatinib-d 8

Overview

N-Desmethyl imatinib -d 8 is a deuterium labeled Imatinib metabolite N-Desmethyl Imatinib ( HY-G0017 ). N‑Desmethyl imatinib (Norimatinib) is an active metabolite of Imatinib ( HY-15463 ), a selective c‑Abl inhibitor, and a substrate of P‑glycoprotein . N-Desmethyl imatinib binds to the c-Abl catalytic domain to prevent substrate phosphorylation, inhibits c-Abl-mediated α-synuclein activation and downstream inflammatory signaling pathways. N-Desmethyl imatinib induces apoptosis in K562 human leukemia cells. N-Desmethyl imatinib exhibits significantly elevated plasma levels in gastrointestinal stromal tumor (GIST) settings following mild SARS CoV 2 infection . N-Desmethyl imatinib can be used for the research of Parkinson’s disease, gastrointestinal stromal tumor, and chronic myeloid leukemia.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Cancer | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Parkinson's Disease | Products > Signaling Pathways > Others | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Neurological Disease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Isotope-Labeled Compounds | Products > Signaling Pathways > Drug Metabolite | Products > Signaling Pathways > P-glycoprotein | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-G0017S
• CAS No.: 1185103-28-9
• Molecular Formula: C28H21D8N7O
• Molecular Weight: 487.63
• Purity: 99.95%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 1.25 mg/mL (2.56 mM); Clear solution
• Availability: In-stock

Source

Original product source