Curdione (Standard)

CAS No.：13657-68-6
Grade：99.98%
Formula：C15H24O2
M.W.：236.35

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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Overview

Curdione (Standard) is the analytical standard of Curdione. This product is intended for research and analytical applications. Curdione ((+)-Curdione) is an orally active sesquiterpenoid. Curdione inhibits platelet aggregation. Curdione induces ferroptosis in colorectal cancer via m6A methylation mediated by METTL14 and YTHDF2 . Curdione inhibits ferroptosis in Isoproterenol ( HY-B0468 )-induced myocardial infarction by regulating the Keap1/Trx1/ GPX4 signaling pathway, suppressing oxidative stress ( ROS ) and apoptosis . Curdione ameliorates Doxorubicin ( HY-15142 )-induced cardiotoxicity by inhibiting oxidative stress ( ROS ) and activating the Nrf2 / HO-1 pathway. Curdione ameliorates sepsis-induced lung injury by inhibiting platelet-mediated neutrophil extracellular trap formation. Curdione ameliorates Bleomycin ( HY-17565A )-induced pulmonary fibrosis by inhibiting TGF-β -induced fibroblast-to-myofibroblast differentiation. Curdione exhibits neuroprotective effects against focal cerebral ischemia-reperfusion injury in rats. Curdione exerts antiproliferative effects against human uterine leiomyosarcoma by targeting IDO1 . Curdione protects vascular endothelial cells and atherosclerosis by regulating DNMT1-mediated ERBB4 promoter methylation. Curdione inhibits inducible prostaglandin E2 production ( IC 50 = 1.1 μM) and cyclooxygenase 2 expression.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Others | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > TGF-beta/Smad | Products > Research Areas > Others | Products > Signaling Pathways > Ferroptosis | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Reactive Oxygen Species (ROS) | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > Glutathione Peroxidase | Products > Signaling Pathways > Keap1-Nrf2 | Products > Signaling Pathways > Heme Oxygenase (HO) | Products > Signaling Pathways > TGF-β Receptor | Products > Signaling Pathways > Indoleamine 2,3-Dioxygenase (IDO) | Products > Signaling Pathways > Reference Standards

Product Information

Catalog No.: HY-N0353R
CAS No.: 13657-68-6
Molecular Formula: C15H24O2
Molecular Weight: 236.35
Purity: 99.98%
Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source

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