Daphnoretin

Overview

Daphnoretin (Dephnoretin; Thymelol) is a protein kinase C ( PKC ) activator that inhibits the expression of hepatitis B virus ( HBV ) surface antigen (HBsAg) and exhibits antiviral activity. Daphnoretin exerts its antitumor effects by inhibiting the activation of the PI3K/AKT signaling pathway and triggers the mitochondrial apoptosis pathway. Daphnoretin alleviates chondrocyte apoptosis and inflammatory responses by inhibiting endoplasmic reticulum stress and activation of the NLRP3 inflammasome. Daphnoretin regulates the differentiation and maturation of dendritic cells, inhibits their immunostimulatory function by downregulating the phosphorylation level of JNK , and thus exerts a protective effect in skin graft rejection.

Application

Products | Products > Disease Areas > Infection | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Viral Infection | Products > Disease Areas > Digestive System Inflammation | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > TGF-beta/Smad | Products > Signaling Pathways > Anti-infection | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Infection | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PKC | Products > Signaling Pathways > Influenza Virus | Products > Signaling Pathways > NOD-like Receptor (NLR) | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > HBV | Products > Signaling Pathways > JNK | Products > Signaling Pathways > PI3K | Products > Signaling Pathways > Akt | Products > Signaling Pathways > CDK | Products > Signaling Pathways > Caspase | Products > Signaling Pathways > Bcl-2 Family

Product Information

• Catalog No.: HY-N0699
• CAS No.: 2034-69-7
• Molecular Formula: C19H12O7
• Molecular Weight: 352.29
• Purity: 99.83%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: 2.08 mg/mL (5.90 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source