Agrimol B, a polyphenol, is an orally active and potent SIRT1 activator. Agrimol B shows anti-adipogenic and anticancer activity. Agrimol B shows antibacterial activity against plant pathogens. Agrimol B dramatically inhibits 3T3-L1 adipocyte differentiation by reducing PPARγ , C/EBPα , FAS , UCP-1 , and apoE expression. The action of Agrimol B on the cancer cells is likely derived from its effect on c-MYC , SKP2 and p27 .
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